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Health Well

Paul Ryan Emerges From Health Care Defeat Badly Damaged

He is now tasked with defending not just his leadership abilities but his very brand of conservatism in a party fitfully searching for a coherent policy identity. ...

Trump Becomes Ensnared in Fiery G.O.P. Civil War

The health bill’s defeat leaves the president facing a wrenching choice: ceding power to his party’s anti-establishment wing, or seeking other pathways to successful governing. ...

VIDEO: New immune targets may improve advanced melanoma outcomes

NEW YORK — Michael A. Postow, MD, medical oncologist at Memorial Sloan Kettering Cancer Center, discussed new immunotherapy targets for advanced melanoma beyond standard targets at HemOnc Today Melanoma and Cutaneous Malignancies.CTLA-4 and PD-1 are the cu ...

VIDEO: Rheumatic diseases attributed to altered relationship with microbial world

WASHINGTON — At the Interdisciplinary Autoimmune Summit, Charles L. Raison, MD, professor at the University of Wisconsin-Madison, gave a summary of his presentation on immune-mediated inflammatory diseases and their relationships with the microbial world.R ...

Anti–PD-1/PD-L1 therapy ‘rapidly becoming’ standard of care for Merkel cell carcinoma

NEW YORK — Immunosuppressive therapies, including anti–PD-1/PD-L1 agents, have led to durable responses among patients with Merkel cell carcinoma. However, more research is needed to fulfill unmet medical needs, according to a presenter at HemOnc Today Mel ...

Challenges remain in determining appropriate sequence of immunotherapy, BRAF/MEK inhibition

NEW YORK — The optimal sequence of immunotherapy and BRAF/MEK inhibition for the first-line treatment of melanoma has only been evaluated retrospectively and remains to be defined, according to a presenter at HemOnc Today Melanoma and Cutaneous Malignancie ...

Going Under the Knife, With Eyes and Ears Wide Open

More people are rejecting general anesthesia for procedures, prompting doctors to narrate their steps as they deal with alert patients asking questions. ...

Hedgehog inhibitors ‘game changers’ for advanced basal cell carcinoma

NEW YORK — Hedgehog inhibitors have demonstrated high efficacy and durability for patients with advanced basal cell carcinoma, according to a speaker at HemOnc Today Melanoma and Cutaneous Malignancies. However, these agents — which included FDA–approved a ...

Baseline factors predict survival benefit from BRAF/MEK inhibitor combination

Baseline lactic acid dehydrogenase levels, the sum of target lesion diameters and the number of organ sites with metastases predicted survival benefit in patients with BRAF V600–mutant melanoma treated with dabrafenib plus trametinib, according to results ...

JAK inhibitors demonstrated efficacy comparable to TNF inhibitors

NEW YORK CITY — At the Interdisciplinary Autoimmune Summit, investigators described the latest research on JAK inhibitors, which demonstrated these are effective and appear to be comparable to tumor necrosis factor inhibitors for rheumatoid arthritis.“Janu ...

Molecular testing requires additional validation before ready for prime time in melanoma

NEW YORK — Preliminary and validation studies have been conducted on molecular testing methods for melanoma prognostication, but these methods have not yet been prospectively validated or incorporated into clinical treatment guidelines, according to a pres ...

New research center will accelerate the development of new antibiotics

Researchers at the University of Liverpool plan to establish the Center for Antimicrobial Pharmacodynamics, or CAP, a research center created to help rapidly develop new antibiotics to treat and manage infections caused by resistant pathogens, according to ...

VIDEO: Decision to undergo lymph node dissection remains ‘complicated’

NEW YORK — Vernon K. Sondak, MD, chair of the department of cutaneous oncology at Moffitt Cancer Center and a HemOnc Today Editorial Board member, discussed the role of completion lymph node dissection in patients with sentinel lymph–node positive melanoma ...

‘Major need’ exists for more effective mucosal melanoma treatments

NEW YORK — Although immunotherapy and targeted agents have demonstrated some promise for mucosal melanoma, outcomes in this patient population remain poor, according to a presenter at HemOnc Today Melanoma and Cutaneous Malignancies.“There is a major need ...

Speaker: Rheumatologists must be prepared for immune-mediated diseases

NEW YORK CITY — While immune-mediated diseases cannot be prevented, rheumatologists must be ready to prepare for the critical decision-making that lies ahead, according to a presentation by Leonard H. Calabrese, DO, at the Interdisciplinary Autoimmune Summ ...

In Major Defeat for Trump, Push to Repeal Health Law Fails

House Republican leaders withdrew legislation to repeal the Affordable Care Act from the House floor before it could be defeated, a loss for President Trump. ...

Cardboard cribs

What evidence is there that Finland's famous baby boxes actually reduce infant mortality rates? ...

MND and schizophrenia are biologically linked

Irish scientists have discovered that motor neurone disease (MND) and schizophrenia have a shared genetic origin. This indicates that the causes of these two conditions are biologically linked, which has major implications for how diseases are classified. ...

New service to help older people remain at home

A new support service, which aims to help older people in north Dublin to remain living independently at home, has been launched. The ALONE charity has partnered with the HSE to provide this vital service to older people throughout the Dublin north city an ...

Teen featured on RTÉ documentary has scoliosis surgery

A 13-year-old scoliosis patient has undergone a long-awaited spine correction operation. ...

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