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Public Health Well

Flu still circulating in Ireland

Thirty-four people have died from flu-related deaths this flu season and the illness is still circulating nationwide, the HSE has said. According to its latest figures, the circulation of flu fell slightly in the community in the week ending February 10 of ...

Negative dysphotopsia improves with occlusion of contralateral eye

ORLANDO — Samuel Masket, MD, has spent a lot of time thinking about negative dysphotopsia and how to improve it. In a presentation at Cataract Surgery: Telling It Like It Is, Masket related findings of a 25-eye pilot study in which patients with ND scotoma ...

Pembrolizumab shows promise for high-risk, BCG-unresponsive nonmuscle-invasive bladder cancer

SAN FRANCISCO — Pembrolizumab induced durable complete responses among patients with high-risk, nonmuscle-invasive, bacillus calmette-guérin-unresponsive bladder carcinoma in situ with or without papillary tumors, according to updated interim results from ...

American Society of Breast Surgeons recommends genetic testing for all patients with breast cancer

All individuals diagnosed with breast cancer should undergo genetic testing with a multigene panel, according to new recommendations from American Society of Breast Surgeons. “I am excited by our new guidelines and look forward to the day when [National Co ...

Circulating tumor cell count may be an effective surrogate endpoint for OS in prostate cancer

SAN FRANCISCO — A reduction to no circulating tumor cells at week 13 appeared to be a stronger indicator of survival outcomes than a 50% or greater reduction in PSA from baseline in phase 2 trials of metastatic castration-resistant prostate cancer, accordi ...

Parents collect respiratory samples earlier in illness than HCWs

Parents in Australia who were trained to collect nasal swabs did so nearly 2 days sooner after their children’s symptoms of an acute respiratory infection appeared compared with home visits by health care workers, according to results of a randomized trial ...

'Immunology boot camp' emphasizes role of chronic stress in autoimmune disease

SCOTTSDALE, Ariz. — Among the most important research in rheumatology over the past two decades has been the role of stress in the onset and course of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus — an interaction that ...

The New Old Age: Dialysis Is a Way of Life for Many Older Patients. Maybe It Shouldn’t Be.

So-called conservative management can ease symptoms without dialysis in some people with kidney disease. But many of them are never given the option. ...

Over 523,000 patients waiting for appointments- NTPF

The number of people waiting on outpatient appointments in public hospitals has risen to more than 523,000, which Fianna Fáil claim is the highest number ever recorded. ...

Provectus ocular melanoma treatment gets orphan drug designation

The FDA has granted an orphan drug designation to PV-10, Provectus BioPharmaceuticals’ ocular melanoma treatment candidate, according to a press release. Rose bengal disodium, also called PV-10, is a small molecule oncolytic immunotherapy delivered via int ...

FDA designates recall of several implanted cardiac pacemakers as class 1

The FDA has designated Medtronic’s product recall of implanted cardiac pacemakers as a class 1 recall, the most serious kind. The recall affects 13,440 devices manufactured and distributed between March 2, 2017, and Jan. 7, 2019. Possible circuit errors in ...

First-line enzalutamide, docetaxel combination improves disease control in advanced prostate cancer

SAN FRANCISCO — The addition of enzalutamide to docetaxel improved 6-month disease control and prolonged PFS as first-line therapy for men with metastatic castration-resistant prostate cancer, according to results from the CHEIRON study presented at Genito ...

CDC includes ‘homelessness’ as indication for hepatitis A vaccine

The CDC recently announced that all persons aged 1 year or older experiencing homelessness should be routinely immunized for hepatitis A, based on a review of recent data. “Among persons experiencing homelessness, effective implementation of alternative st ...

Hand-to-genital contact unlikely to cause HPV transmission

HPV transmission is unlikely to occur from hand-to-genital contact, and most infections are caused by genital-to-genital sexual transmission, according to a recent study published in The Lancet Infectious Diseases. “While hand-to-genital transmission has l ...

Age, radiographic OA seen as main drivers of appropriate use criteria for hip preservation surgery

Variables that contributed the most to the appropriateness classification system for hip preservation surgery published by the American Academy of Orthopaedic Surgeons included age and radiographic hip osteoarthritis evaluation, according to results. “Vari ...

Nivolumab plus ipilimumab shows activity in metastatic castration-resistant prostate cancer

SAN FRANCISCO — Nivolumab plus ipilimumab demonstrated activity in pretreated men with metastatic castration-resistant prostate cancer, according to initial findings from the phase 2 CheckMate 650 study presented at Genitourinary Cancers Symposium. In addi ...

Text message-based intervention shows promise for suicide prevention

Augmenting standard care with a text message-based intervention, known as Caring Contacts, did not decrease current suicidal ideation or suicide risk events at 12-month follow-up among active-duty military personnel in a randomized clinical trial. However, ...

FDA grants priority review to Keytruda as part of advanced kidney cancer regimen

The FDA granted priority review for a supplemental biologics license application seeking approval of pembrolizumab in combination with axitinib for first-line treatment of patients with advanced renal cell carcinoma, according to a press release from the m ...

Ascletis, 3-V Biosciences raise $18 million for phase 2 NASH therapy

3-V Biosciences has entered an exclusive license agreement with Ascletis Pharma for Ascletis to develop, manufacture and commercialize 3-V Biosciences’ nonalcoholic steatohepatitis therapy TVB-2640 in Greater China, according to a press release. 3-V Biosci ...

Small intestine bacterial overgrowth prevalence drastically higher in patients with IBD

There is a ninefold increase in the prevalence of small intestine bacterial overgrowth among patients with inflammatory bowel disease compared with other individuals, according to results of a meta-analysis. Gerald J. Holtmann, MD, PhD, MBA, of Princess Al ...