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Health Well

Acute Effects of Viral Exposure on P-Glyco-protein Function in the Mouse Fetal Blood-Brain Barrier

Background/Aims: Viral infection during pregnancy is known to affect the fetal brain. The toll-like receptor (TLR)-3 is a pattern recognition receptor activated by viruses known to elicit adverse fetal neurological outcomes. The P-glycoprotein (P-gp) effl ...

High Glucose Induces Mouse Mesangial Cell Overproliferation via Inhibition of Hydrogen Sulfide Synthesis in a TLR-4-Dependent Manner

Background/Aims: Overproliferation of mesangial cells was believed to play an important role in the progress of diabetic nephropathy, one of the primary complications of diabetes. Hydrogen sulfide (H2S), a well-known and pungent gas with the distinctive s ...

Handing NHS data to the Home Office

What is the agreement between the NHS and the Home Office?A memorandum of understanding published in January revealed that NHS Digital must give the Home Office information about patients it believes... ...

Support swells across UK in day of action for migrant workers

bmj;356/feb22_1/j943/FAF1faJack Taylor/Getty ImagesNHS staff joined thousands of people across the UK in a day of action on Monday 20 February to celebrate the contribution of migrant workers and EU... ...

Still waiting for…

Dara Gantly Dara Gantly offers some pointers on addressing our ever-growing waiting lists ...

The ‘F’ word is not a dirty one in North West

Dr Ruari Hanley Dr Ruairi Hanley believes that with proper safeguards and regulation, fracking could hold massive potential for the hard-hit regions of Leitrim, West Cavan and Fermanagh I will begin this week by telling readers of a small part of Ireland ...

Professionals should act on instincts if they suspect child abuse, NICE says

Professionals who work with children should be curious about “soft signs” that could signal abuse or neglect, a draft guideline from the National Institute for Health and Care Excellence (NICE)... ...

Professionals should act on instincts if they suspect child abuse, NICE says

Professionals who work with children should be curious about “soft signs” that could signal abuse or neglect, a draft guideline from the National Institute for Health and Care Excellence (NICE)... ...

Testosterone increases coronary artery plaque in older men but helps anaemia and bone density

Testosterone treatment increased the amount of coronary artery non-calcified plaque rather than reducing this early sign of increased cardiovascular risk in older men with low testosterone levels, a... ...

CADASIL: Ultrastructural insights into the morphology of granular osmiophilic material

Abstract Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary systemic vascular disorder. Granular osmiophilic material (GOM) is its ultrastructural marker. We reviewed tissue bio ...

Bacterial cell-to-cell signaling promotes the evolution of resistance to parasitic bacteriophages

Abstract The evolution of host–parasite interactions could be affected by intraspecies variation between different host and parasite genotypes. Here we studied how bacterial host cell-to-cell signaling affects the interaction with parasites using two bacte ...

Challenges to conducting epidemiology research in chronic conflict areas: examples from PURE- Palestine

Little has been written on the challenges of conducting research in regions or countries with chronic conflict and strife. In this paper we share our experiences in conducting a population based study of chron... ...

IJERPH, Vol. 14, Pages 217: Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011–June 2015

Given the rapid rate of global spread and consequently healthcare costs related to influenza, surveillance plays an important role in monitoring the emerging pandemics in China. However, the characteristics of influenza in Southeast of China haven’t been f ...

IJERPH, Vol. 14, Pages 216: DNA Methylation Status of PAX1 and ZNF582 in Esophageal Squamous Cell Carcinoma

Hypermethylation of specific gene promoters is an important mechanism of carcinogenesis. A high frequency of promoter methylation of PAX1 and ZNF582 genes has been detected in cervical cancer. In the present study, we investigated the methylation status of ...

IJERPH, Vol. 14, Pages 215: Removal Capacities of Polycyclic Aromatic Hydrocarbons (PAHs) by a Newly Isolated Strain from Oilfield Produced Water

The polycyclic aromatic hydrocarbon (PAH)-degrading strain Q8 was isolated from oilfield produced water. According to the analysis of a biochemical test, 16S rRNA gene, house-keeping genes and DNA–DNA hybridization, strain Q8 was assigned to a novel specie ...

Oil and the Golden Constant

Steve H. Hanke Since its recent high of almost $108/bbl in June 2014, we have witnessed a stunning collapse, and a subsequent bounce back, in the price of oil. In February 2016, West Texas Intermediate (WTI) was trading at $26/bbl, a 76% plunge from its J ...

The Law and Disorder Presidency

Alex Nowrasteh ...

Blocking IL-17A Alleviates Diabetic Retinopathy in Rodents

Background/Aims: Interleukin (IL)-17A, a proinflammatory cytokine, has been implicated in several autoimmune diseases. However, it is unclear whether IL-17A is involved in diabetic retinopathy (DR), one of the most serious complications of autoimmune diab ...

Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion

Background/Aims: A major challenge for current therapeutic strategies against ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) to improve the systolic/dia ...

SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells

Background: It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo. However, few studies have examined the relationship between SUMO gene silencing and gastric c ...

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