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The transsulfuration pathway : a source of cysteine for glutathione in astrocytes

Creator:

McBean, Gethin J.;

Institution: Springer
Subject Keywords: Transulfuration; Brain; Astrocyte; Cysteine; Cystathionine-gamma-lyase; Cystathionine-beta-synthase; Glutathione;
Region:
Description:

Astrocyte cells require cysteine as a substrate for glutamate cysteine ligase (γ-glutamylcysteine synthase; EC 6.3.2.2) catalyst of the rate-limiting step of the γ-glutamylcycle leading to formation of glutathione (l-γ-glutamyl-l-cysteinyl-glycine; GSH). In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c − cystine-glutamate exchanger. However, the transsulfuration pathway, which supplies cysteine from the indispensable amino acid, methionine, has recently been identified as a significant contributor to GSH synthesis in astrocytes. The purpose of this review is to evaluate the importance of the transsulfuration pathway in these cells, particularly in the context of a reserve pathway that channels methionine towards cysteine when the demand for glutathione is high, or under conditions in which the supply of cystine by the x c − exchanger may be compromised.

Related: http://dx.doi.org/10.1007/s00726-011-0864-8
Suggested citation:

McBean, Gethin J.; . () The transsulfuration pathway : a source of cysteine for glutathione in astrocytes [Online]. Available from: http://publichealthwell.ie/node/668995 [Accessed: 20th October 2019].

  

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