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Transport and Retinal Capture of Luteinand Zeaxanthin with Reference to Age-related Macular Degeneration

Creator:

Loane E, Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Abstract.Age-related macular degeneration (AMD) is the most common cause of irreversibleblindness in the elderly population in the western world. The etiology and pathogenesis of this diseaseremain unclear. However, there is an increasing body of evidence supporting the hypothesis that themacular pigment carotenoids, lutein and zeaxanthin, play an important role in protection againstAMD, by filtering out blue light at a pre-receptoral level, or by quenching free radicals. Lutein andzeaxanthin are dietary xanthophyll carotenoids, which are delivered to the retina via plasmalipoproteins. The biological mechanisms governing retinal capture and accumulation of lutein andzeaxanthin, to the exclusion of other carotenoids, are still poorly understood. Although thesemechanisms remain unclear, it is possible that selective capture of these carotenoids is related tolipoprotein, or apolipoprotein, function and profile. Xanthophyll-binding proteins appear to play animportant role in the retinal capture of the xanthophyll carotenoids. The Pi isoform of GSTP1 hasbeen isolated as a specific binding protein for zeaxanthin. The binding protein responsible for retinaluptake of lutein remains elusive. This article reviews the literature germane to the mechanismsinvolved in the capture, accumulation and stabilization of lutein and zeaxanthin by the retina, and theprocesses involved in their transport in serum. (Surv Ophthalmol 53:68--81, 2008.Ó2008 ElsevierInc. All rights reserved.)

Date:

01/01/2008

Rights: © Public
Suggested citation:

Loane E, Nolan JM, O'Donovan O, Bhosale P, Bernstein PS, Beatty S. (2008) Transport and Retinal Capture of Luteinand Zeaxanthin with Reference to Age-related Macular Degeneration [Online]. Available from: http://publichealthwell.ie/node/1264602 [Accessed: 17th September 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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