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Supplementation With Three Different Macular Carotenoid Formulations in Patients With Early Age-Related Macular Degeneration.

Creator:

Loughman, James; Sabour-Pickett, Sarah; Beatty, Stephen; Connolly, Eithne; Stack, Jim; Howard, Alan; Klein, Ronald; Klein, Barbara E.; Meuer, Stacy M; Myers, Chelsea E.; Akuffo, Kwadwo O.; Nolan, John M;

Institution: Dublin Institute of Technology
Subject Keywords: macular carotenoid formulation; macular degeneration.; Ophthalmology;
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Description:

Purpose: To investigate the impact of three different macular carotenoid formulations on macular pigment optical density and visual performance in subjects with early age-related macular degeneration. Methods: Fifty-two subjects were supplemented and followed for 12 months, 17 of them were in intervention Group 1 (20 mg/day lutein and 2 mg/day zeaxanthin); 21 in Group 2 (10 mg/day meso-zeaxanthin, 10 mg/day lutein, and 2 mg/day zeaxanthin); and 14 in Group 3 (17 mg/day meso-zeaxanthin, 3 mg/day lutein, and 2 mg/day zeaxanthin). The macular pigment optical density was measured using customized heterochromatic flicker photometry, and visual function was assessed using corrected distance visual acuity and by letter contrast sensitivity. Results: A statistically significant increase in the macular pigment optical density was observed at all measured eccentricities in Group 2 (P # 0.005) and in Group 3 (P , 0.05, for all), but only at 1.75° in Group 1 (P = 0.018). Statistically significant (P , 0.05) improvements in letter contrast sensitivity were seen at all spatial frequencies (except 1.2 cycles per degree) in Group 3, and at low spatial frequencies in Groups 1 and 2. Conclusion: Augmentation of the macular pigment optical density across its spatial profile and enhancements in contrast sensitivity were best achieved after supplementation with a formulation containing high doses of meso-zeaxanthin in combination with lutein and zeaxanthin.

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Suggested citation:

Loughman, James; Sabour-Pickett, Sarah; Beatty, Stephen; Connolly, Eithne; Stack, Jim; Howard, Alan; Klein, Ronald; Klein, Barbara E.; Meuer, Stacy M; Myers, Chelsea E.; Akuffo, Kwadwo O.; Nolan, John M; . () Supplementation With Three Different Macular Carotenoid Formulations in Patients With Early Age-Related Macular Degeneration. [Online]. Available from: http://publichealthwell.ie/node/845061 [Accessed: 15th September 2019].

  

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