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Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration

Creator:

Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

AbstractMacular pigment (MP) is composed of lutein (L), zeaxanthin (Z) andmeso-zeaxanthin (MZ). The present study reports on serum response tothree different MP supplements in normal subjects (n27) and in subjects with age-related macular degeneration (AMD) (n27). Subjects wererandomly assigned to: Group 1 (20 mg L and 2 mg Z), Group 2 (10 mg L, 2 mg Z and 10 mg MZ) or Group 3 (3 mg L, 2 mg Z and 17 mg MZ). Serumcarotenoids were quantified at baseline, and at 4 and 8 weeks using HPLC. Response data for normal and AMD subjects were comparable andtherefore combined for analysis. We report response as the average of the 4- and 8-week concentrations (saturation plateau). Serum L increasedsignificantly in Group 1 (0·036mmol/l per mg (269 %);P,0·001) and Group 2 (0·079mmol/l per mg (340 %);P,0·001), with no significantchange in Group 3 (0·006mmol/l per mg (7%);P¼0·466). Serum Z increased significantly in Group 1 (0·037mmol/l per mg (69 %);P¼0·001)and Group 2 (0·015mmol/l per mg (75 %);P,0·001), with no significant change in Group 3 (20·0002mmol/l per mg (26 %);P¼0·384).Serum MZ increased significantly in Group 1 (0·0094mmol/l (absolute value);P¼0·015), Group 2 (0·005mmol/l per mg;P,0·001) andGroup 3 (0·004mmol/l per mg;P,0·001). The formulation containing all three macular carotenoids (Group 2 supplement) was the mostefficacious in terms of achieving the highest combined concentration of the three MP constituent carotenoids in serum, thereby potentiallyoptimising the bioavailability of these compounds for capture by the target tissue (retina).

Date:

30/09/2012

Rights: © Public
Suggested citation:

Meagher KA, Thurnham DI, Beatty S, Howard AN, Connolly E, Cummins W, Nolan JM. (2012) Serum response to supplemental macular carotenoids in subjects with and without age-related macular degeneration [Online]. Available from: http://publichealthwell.ie/node/1264335 [Accessed: 19th August 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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