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Serum and macular response to carotenoid-enriched egg supplementationin human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT)

Creator:

Kelly D. Nolan JM. Howard AN. Stack J. Akuffo KO. Moran R. Themham DI. Dennison J. Meagher KA. Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

AbstractThe macular carotenoids lutein (L), zeaxanthin (Z) andmeso-zeaxanthin (MZ) accumulate at the macula, where they are collectively referredto as macular pigment (MP). Augmentation of this pigment, typically achieved through diet and supplementation, enhances visual functionand protects against progression of age-related macular degeneration. However, it is known that eggs are a rich dietary source of L and Z, in ahighly bioavailable matrix. In this single-blind placebo-controlled study, L- and MZ-enriched eggs and control non-enriched eggs were fed tohuman subjects (mean age 41 and 35 years, respectively) over an 8-week period, and outcome measures included MP, visual function andserum concentrations of carotenoids and cholesterol. Serum carotenoid concentrations increased significantly in control and enriched egggroups, but to a significantly greater extent in the enriched egg group (P<0·001 for L, Z and MZ). There was no significant increase in MP ineither study group post intervention, and we saw no significant improvement in visual performance in either group. Total cholesterolincreased significantly in each group, but it did not exceed the upper limit of the normative range (6·5 mmol/l). Therefore, carotenoid-enrichedeggs may represent an effective dietary source of L, Z and MZ, reflected in significantly raised serum concentrations of these carotenoids, andconsequentially improved bioavailability for capture by target tissues. However, benefits in terms of MP augmentation and /or improved visualperformance were not realised over the 8-week study period, and a study of greater duration will be required to address these questions.

Date:

11/10/2016

Rights: © Public
Suggested citation:

Kelly D. Nolan JM. Howard AN. Stack J. Akuffo KO. Moran R. Themham DI. Dennison J. Meagher KA. Beatty S . (2016) Serum and macular response to carotenoid-enriched egg supplementationin human subjects: the Egg Xanthophyll Intervention clinical Trial (EXIT) [Online]. Available from: http://publichealthwell.ie/node/1264168 [Accessed: 15th September 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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