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Risk Factors for Age-Related Maculopathy


Connell PP, Keane PA, O'Neill EC, Altaie RW, Loane E, Neelam K, Nolan JM, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland

Age-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies haverecently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies haveenhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions withrespect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factorsfor ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies,case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrumof epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated torepresent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmentaland genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an importantrole in the pathogenesis of this condition.



Rights: © Public
Suggested citation:

Connell PP, Keane PA, O'Neill EC, Altaie RW, Loane E, Neelam K, Nolan JM, Beatty S. (2009) Risk Factors for Age-Related Maculopathy [Online]. Available from: [Accessed: 22nd August 2019].


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