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Risk factors for age-related maculopathy are associated with a relative lack of macular pigment

Creator:

Nolan JM, Stack J, O'Donovan O, Loane E, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Abstract

Macular pigment (MP) is composed of the two dietary carotenoids lutein (L) and zeaxanthin (Z), and is believed to protect against age-relatedmaculopathy (ARM). This study was undertaken to investigate MP optical density with respect to risk factors for ARM, in 828 healthy subjectsfrom an Irish population. MP optical density was measured psychophysically using heterochromatic flicker photometry, serum L and Z werequantified by HPLC, and dietary intake of L and Z was assessed using a validated food-frequency questionnaire. Clinical and personal detailswere also recorded, with particular attention directed towards risk factors for ARM. We report a statistically significant age-related decline in MPoptical density (r2¼0.082,p<0.01). Current and past smokers had lower average MP optical density than never smokers and this differencewas statistically significant (p<0.01). Subjects with a confirmed family history of ARM had significantly lower levels of MP optical densitythan subjects with no known family history of disease (p<0.01). For each of these established risk factors, their statistically significant negativeassociation with MP persisted after controlling for the other two, and also after controlling for other potentially confounding variables such assex, cholesterol, dietary and serum L (p<0.01). In the absence of retinal pathology, and in advance of disease onset, the relative lack of MPseen in association with increasing age, tobacco use and family history of ARM supports the hypothesis that the enhanced risk that these vari-ables represent for ARM may be attributable, at least in part, to a parallel deficiency of macular carotenoids

Date:

01/11/2006

Rights: © Public
Suggested citation:

Nolan JM, Stack J, O'Donovan O, Loane E, Beatty S. (2006) Risk factors for age-related maculopathy are associated with a relative lack of macular pigment [Online]. Available from: http://publichealthwell.ie/node/1264605 [Accessed: 25th August 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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