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A review of the evidence germane to the putative protective role of the macular carotenoids forage-related macular degeneration

Creator:

Sabour-Pickett S, Nolan JM, Loughman J, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

There is a consensus that age-related macular degeneration (AMD) is the result of (photo)-oxidative-induced retinal injury and its inflammatory sequelae, the latter being influenced bygenetic background. The dietary carotenoids, lutein (L), zeaxanthin (Z), andmeso-zeaxanthin(meso-Z), accumulate at the macula, where they are collectively known as macular pigment(MP). The anatomic (central retinal), biochemical (anti-oxidant) and optical (short-wave-length-filtering) properties of this pigment have generated interest in the biologically plau-sible rationale that MP may confer protection against AMD. Level 1 evidence has shown thatdietary supplementation with broad-spectrum anti-oxidants results in risk reduction for AMDprogression. Studies have demonstrated that MP rises in response to supplementation withthe macular carotenoids, although level 1 evidence that such supplementation results in riskreduction of AMD and/or its progression is still lacking. Although appropriately weightedattention should be accorded to higher levels of evidence, the totality of available data shouldbe appraised in an attempt to inform professional practice. In this context, the literaturedemonstrates that supplementation with the macular carotenoids is probably the best meansof fortifying the anti-oxidant defences of the macula, thus putatively reducing the risk of AMDand/or its progression

Date:

18/08/2011

Rights: © Public
Suggested citation:

Sabour-Pickett S, Nolan JM, Loughman J, Beatty S. (2011) A review of the evidence germane to the putative protective role of the macular carotenoids forage-related macular degeneration [Online]. Available from: http://publichealthwell.ie/node/1264340 [Accessed: 21st September 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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