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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Creator:

Nature Journal

Type: Report
Region: Republic of Ireland
Northern Ireland
Description:

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development. The current model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neoplasm (PanINs) lesions, makes two predictions: first, that pancreatic cancer develops through a particular sequence of genetic alterations (KRAS, followed by CDKN2A, then TP53 and SMAD4); and second, that the evolutionary trajectory of pancreatic cancer progression is gradual because each alteration is acquired independently.

 

Date:

13/10/2016

Rights: Public
Suggested citation:

Nature Journal. (2016) A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns [Online]. Available from: http://publichealthwell.ie/node/1039188 [Accessed: 18th March 2019].

  

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Contributor:

Northern Ireland Cancer Network (NICaN)
 
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