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The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample

Creator:

Moran R. Beatty S. Stack J. O'Halloran QAM. Feeney J. Akuffo KO. Peto T. Kenny RA. Nolal JM

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Abstract.

Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed andself-reported prevalence of age-related macular degeneration (AMD).Material and methods: Data collected from a nationally representative prospective cohort study ofcommunity-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwenta computer-assisted personal interview and a center-based health assessment. Plasma concentrations ofL and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatogra-phy, and retinal photographs were graded using a version of the AMD International Classification andGrading System. Consumption of supplements containing L and/or Z and/or MZ was recorded assupplement use. Four groups were identified: Group 1 (n= 24): AMD-afflicted and correctly aware;Group 2 (n= 264): AMD-afflicted but unaware; Group 3 (n= 41): AMD-free and incorrectly believed thatthey were afflicted with the condition; Group 4 (n= 4094): AMD-free and correctly self-reported absenceof AMD.Results: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs,288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history andage, the relationship between grading-confirmed AMD and plasma L was positive and significant(p< 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 μmol) and Group 4(mean = 0.2040 ± 0.121 μmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 μmol/L)and Group 3 (mean = 0.3176 ± 0.0.235 μmol/L). Supplement use was reported by 41.7% and 17.1% ofparticipants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4,respectively.Conclusion: A belief that one suffers from AMD, whether justified or not, is associated with supplementuse and with higher plasma concentrations of L.

Date:

02/11/2017

Rights: © Public
Suggested citation:

Moran R. Beatty S. Stack J. O'Halloran QAM. Feeney J. Akuffo KO. Peto T. Kenny RA. Nolal JM. (2017) The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample [Online]. Available from: http://publichealthwell.ie/node/1264159 [Accessed: 18th October 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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