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Psychophysical Function in Age-related Maculopathy


Neelam K, Nolan JM, Chakravarthy U, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland

Abstract.Age-related macular degeneration (AMD), the late stage of age-related maculopathy(ARM), is the leading cause of blind registration in developed countries. The visual loss in AMD occursdue to dysfunction and death of photoreceptors (rods and cones) secondary to an atrophic ora neovascular event. The psychophysical tests of vision, which depend on the functional status of thephotoreceptors, may detect subtle alterations in the macula before morphological fundus changes areapparent ophthalmoscopically, and before traditional measures of visual acuity exhibit deterioration,and may be a useful tool for assessing and monitoring patients with ARM. Furthermore, worsening ofthese visual functions over time may reflect disease progression, and some of these, alone or incombination with other parameters, may act as a prognostic indicator for identifying eyes at risk fordeveloping neovascular AMD. Lastly, psychophysical tests often correlate with subjective and relativelyundefined symptoms in patients with early ARM, and may reflect limitation of daily activities for ARMpatients. However, clinical studies investigating psychophysical function have largely been cross-sectional in nature, with small sample sizes, and lack consistency in terms of the grading andclassification of ARM. This article aims to comprehensively review the literature germane topsychophysical tests in ARM, and to furnish the reader with an insight into this complex area ofresearch. (Surv Ophthalmol54:167--210, 2009.Ó2009 Elsevier Inc. All rights reserved.).



Rights: © Public
Suggested citation:

Neelam K, Nolan JM, Chakravarthy U, Beatty S. (2009) Psychophysical Function in Age-related Maculopathy [Online]. Available from: [Accessed: 21st September 2019].


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