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Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients

Creator:

ademowo OS. Dias HK. Milic I. Devitt A. Moran R. Mulcahy R. Howard AN. Nolan JM

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Alzheimer's disease (AD) is a progressive, neurodegenerative disease, characterised by decline of memory,cognitive function and changes in behaviour. Generic markers of lipid peroxidation are increased in AD andreactive oxygen species have been suggested to be involved in the aetiology of cognitive decline. Carotenoids aredepleted in AD serum, therefore we have compared serum lipid oxidation between AD and age-matched controlsubjects before and after carotenoid supplementation. The novel oxidised phospholipid biomarker 1-palmitoyl-2-(5-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC) was analysed using electrospray ionisation tandem massspectrometry (MS) with multiple reaction monitoring (MRM), 8-isoprostane (IsoP) was measured by ELISA andferric reducing antioxidant potential (FRAP) was measured by a colorimetric assay.AD patients (n=21) and healthy age-matched control subjects (n=16) were supplemented with eitherMacushield(10 mg meso-zeaxanthin, 10 mg lutein, 2 mg zeaxanthin) or placebo (sunflower oil) for six months.The MRM-MS method determined serum POVPC sensitively (from 10 μl serum) and reproducibly(CV=7.9%). At baseline, AD subjects had higher serum POVPC compared to age-matched controls,(p=0.017) and cognitive function was correlated inversely with POVPC (r=0.37; p=0.04). After six monthsof carotenoid intervention, serum POVPC was not different in AD patients compared to healthy controls.However, POVPC was significantly higher in control subjects after six months of carotenoid interventioncompared to their baseline (p=0.03). Serum IsoP concentration was unrelated to disease or supplementation.Serum FRAP was significantly lower in AD than healthy controls but was unchanged by carotenoid intervention(p=0.003).In conclusion, serum POVPC is higher in AD patients compared to control subjects, is not reduced bycarotenoid supplementation and correlates with cognitive function.

 

Date:

11/03/2017

Rights: © Public
Suggested citation:

ademowo OS. Dias HK. Milic I. Devitt A. Moran R. Mulcahy R. Howard AN. Nolan JM. (2017) Phospholipid oxidation and carotenoid supplementation in Alzheimer’s disease patients [Online]. Available from: http://publichealthwell.ie/node/1264164 [Accessed: 16th September 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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