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Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin

Creator:

Beatty S, Nolan JM, Kavanagh H, O'Donovan O

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Abstract

Observational evidence is accumulating that the onset of age-related maculopathy, the leading cause of legal blindness in theWestern World, could be delayed, or even averted, with antioxidant supplements. Lutein (L) and zeaxanthin (Z) are two hydroxy-carotenoids with antioxidant activity which accumulate at the macula, where they are collectively known as macular pigment (MP).It has been shown that MP is entirely of dietary origin, and that L and Z levels in serum, diet, and retina correlate. However, thenature of the relationships between L and Z in foodstuffs, blood, and macula is confounded by many variables including processeswhich influence digestion, absorption, and transport of the compounds in question, and accumulation and stabilization of thecarotenoids in the tissues. If macular pigment is protective for age-related maculopathy, a clear understanding of the mechanismswhereby L and Z arrive at the target tissue (retina) from their source (foodstuff) is essential. In this paper, we review the literaturegermane to this growing area of interest.

Date:

10/04/2004

Rights: © Public
Suggested citation:

Beatty S, Nolan JM, Kavanagh H, O'Donovan O. (2004) Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin [Online]. Available from: http://publichealthwell.ie/node/1264610 [Accessed: 25th August 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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