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Macular Pigment and its Correlation with Colour Vision and SWAP Perimetry

Creator:

Loughman, James; Davison, Peter; Scanlon, Grainne;

Institution: Dublin Institute of Technology
Subject Keywords: macular pigment; short wavelength automated perimetry; colour vision; 100 hue; 3. MEDICAL AND HEALTH SCIENCES, Ophthalmology; Medicine and Health Sciences;
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Purpose To investigate the effects of macular pigment optical density (MPOD) on colour vision and colour modulated visual fields using short-wavelength automated perimetry (SWAP). Methods Macular pigment (MP) spatial profile was measured using customised heterochromatic flicker photometry (cHFP) on 51 normal subjects. Colour vision was assessed using the Oculus anomaloscope [Moreland equation (AME)] and Farnsworth-Munsell 100-Hue (FM) with optimum confusion axes. A custom designed program on the Humphrey automated perimeter, was used to determine SWAP thresholds at the fovea, and at each degree of retinal eccentricity for the central five degrees. A 440nm Goldmann V stimulus presented on a 100cd/m2 bleaching background was used to isolate the short wave sensitive pathway. Results While inter-relationships were evident between AME, FM and SWAP, only one colour vision measure (on FM) correlated with MPOD (r=.302, p= 0.03). At similar degrees of eccentricity, SWAP was inversely and statistically significantly correlated with MPOD (e.g. 1-degree retinal eccentricity: r = -0.198, p = 0.047; 3 degrees retinal eccentricity r = -0.290, p = 0.03). Conclusion Colour vision, even using sensitive tests targeting blue-yellow and blue-green confusion is surprisingly independent of MPOD, while SWAP sensitivity is reduced with increased MPOD. We hypothesize that this is due to long-term adaptation of the retinal blue-yellow pathway to prevailing MPOD in normal subjects, this adaptation being upset by short-term chromatic adaptation in SWAP.

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Suggested citation:

Loughman, James; Davison, Peter; Scanlon, Grainne; . () Macular Pigment and its Correlation with Colour Vision and SWAP Perimetry [Online]. Available from: http://publichealthwell.ie/node/638304 [Accessed: 12th November 2019].

  

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