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Leptin Regulates Striatal Regions and Human Eating Behavior

Creator:

Farooqi, I. S. Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S. and Fletcher, P. C.

Subject Keywords: Study on physiological satiety signals and overeating.
Topic: Obesity
Cardiovascular Health (Draft)
Type: Article
Region: United Kingdom
Description:

Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. The authors used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.

Date:

01/06/2005

Rights: © Farooqi, I. S. Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S. and Fletcher, P. C.
Suggested citation:

Farooqi, I. S. Bullmore, E., Keogh, J., Gillard, J., O'Rahilly, S. and Fletcher, P. C.. (2005) Leptin Regulates Striatal Regions and Human Eating Behavior [Online]. Available from: http://publichealthwell.ie/node/3968 [Accessed: 19th August 2019].

  

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