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The Impact of Supplemental Macular Carotenoids in Alzheimer’s Disease:A Randomized Clinical Trial

Creator:

Nolan JM. Loskutova E. Howard A. Mulcahy R. Stack J. Bolger M. Coen RF. Dennison J. Akuffo KO. Owens N.Power R. Thurnham D. Beatty S.

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

Abstract.Background:Patients with Alzheimer’s disease (AD) exhibit significantly less macular pigment (MP) and poorer vision whencompared to control subjects.Objective:To investigate supplementation with the macular carotenoids on MP, vision, and cognitive function in patients withAD versus controls.Methods:A randomized, double-blind clinical trial with placebo and active arms. 31 AD patients and 31 age-similar controlsubjects were supplemented for six months with either Macushield (10 mg meso-zeaxanthin [MZ]; 10 mg lutein [L]; 2 mgzeaxanthin [Z]) or placebo (sunflower oil). MP was measured using dual-wavelength autofluorescence (Heidelberg Spectralis®).Serum L, Z, and MZ were quantified by high performance liquid chromatography. Visual function was assessed by best correctedvisual acuity and contrast sensitivity (CS). Cognitive function was assessed using a battery of cognition tests, including theCambridge Neuropsychological Test Automated Battery (CANTAB).Results:Subjects on the active supplement (for both AD and non-AD controls) exhibited statistically significant improvementin serum concentrations of L, Z, MZ, and MP (p< 0.001, for all) and also CS at (p= 0.039). Also, for subjects on the activesupplement, paired samplest-tests exhibited four significant results (from five spatial frequencies tested) in the AD group, andtwo for the non-AD group, and all indicating improvements in CS. We found no significant changes in any of the cognitivefunction outcome variables measured (p> 0.05, for all).Conclusion:Supplementation with the macular carotenoids (MZ, Z, and L) benefits patients with AD, in terms of clinicallymeaningful improvements in visual function and in terms of MP augmentation.

Date:

15/10/2014

Rights: © Public
Suggested citation:

Nolan JM. Loskutova E. Howard A. Mulcahy R. Stack J. Bolger M. Coen RF. Dennison J. Akuffo KO. Owens N.Power R. Thurnham D. Beatty S.. (2014) The Impact of Supplemental Macular Carotenoids in Alzheimer’s Disease:A Randomized Clinical Trial [Online]. Available from: http://publichealthwell.ie/node/1264180 [Accessed: 19th August 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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