menu ☰
menu ˟

The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related MacularDegeneration: A Head-to-Head Randomized Clinical Trial

Creator:

Akuffo KO. Beatty S. Peto T. Stack J. Stringham J. Kelly D. Leung I. Corcoran L. Nolan JM

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

PURPOSE.The purpose of this study was to evaluate the impact of supplemental macularcarotenoids (including versus not includingmeso-zeaxanthin) in combination withcoantioxidants on visual function in patients with nonadvanced age-related maculardegeneration.METHODS.In this study, 121 participants were randomly assigned to group 1 (Age-Related EyeDisease Study 2 formulation with a low dose [25 mg] of zinc and an addition of 10 mgmeso-zeaxanthin;n¼60) or group 2 (Age-Related Eye Disease Study 2 formulation with a low dose[25 mg] of zinc;n¼61). Visual function was assessed using best-corrected visual acuity,contrast sensitivity (CS), glare disability, retinal straylight, photostress recovery time, readingperformance, and the National Eye Institute Visual Function Questionnaire-25. Macularpigment was measured using customized heterochromatic flicker photometry.RESULTS.There was a statistically significant improvement in the primary outcome measure(letter CS at 6 cycles per degree [6 cpd]) over time (P¼0.013), and this observedimprovement was statistically comparable between interventions (P¼0.881). Statisticallysignificant improvements in several secondary outcome visual function measures (letter CS at1.2 and 2.4 cpd; mesopic and photopic CS at all spatial frequencies; mesopic glare disability at1.5, 3, and 6 cpd; photopic glare disability at 1.5, 3, 6, and 12 cpd; photostress recovery time;retinal straylight; mean and maximum reading speed) were also observed over time (P<0.05,for all), and were statistically comparable between interventions (P>0.05, for all).Statistically significant increases in macular pigment at all eccentricities were observed overtime (P<0.0005, for all), and the degree of augmentation was statistically comparablebetween interventions (P>0.05).CONCLUSIONS.Antioxidant supplementation in patients with nonadvanced age-related maculardegeneration results in significant increases in macular pigment and improvements in CS andother measures of visual function. (Clinical trial, http://www.isrctn.com/ISRCTN13894787).Keywords:randomized clinical trial, lutein, zeaxanthin,meso-zeaxanthin, macular pigment,age-related macular degeneration, visual function, visual acuity, contrast sensitivity, macularpigment, NEI VFQ-25, photostress recovery time, reading performance, glare disability, retinalstraylight.

Date:

10/09/2017

Rights: © Public
Suggested citation:

Akuffo KO. Beatty S. Peto T. Stack J. Stringham J. Kelly D. Leung I. Corcoran L. Nolan JM. (2017) The Impact of Supplemental Antioxidants on Visual Function in Nonadvanced Age-Related MacularDegeneration: A Head-to-Head Randomized Clinical Trial [Online]. Available from: http://publichealthwell.ie/node/1264163 [Accessed: 15th September 2019].

  

View your saved citations and reading lists

Contributor:

Nutritional Research Centre Ireland (NRCI)
 
Click here to view all the resources gathered from this organisation's website.