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The impact of macular pigment augmentation on visual performancein normal subjects: COMPASS

Creator:

Nolan JM, Loughman J, Akkali MC, Stack J, Scanlon G, Davison P, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland
Description:

This study was conducted to investigate whether augmentation of macular pigment (MP) enhances visualperformance (VP). 121 normal subjects were recruited. The active (A) group consumed 12 mg of lutein (L)and 1 mg of zeaxanthin (Z) daily. MP optical density (MPOD) was assessed by customized heterochro-matic flicker photometry. VP was assessed as best corrected visual acuity (BCVA), mesopic and photopiccontrast sensitivity (CS), glare disability, photostress, and subjective visual function. Subjects wereassessed at baseline; 3; 6; 12 months (V1, V2, V3 and V4, respectively). Central MPOD increased signif-icantly in the A group (p< 0.05) but not in the placebo group (p> 0.05). This statistically significantincrease in MPOD in the A group was not, in general, associated with a corresponding improvement inVP (p> 0.05, for all variables), with the exception of a statistically significant time/treatment effect in‘‘daily tasks comparative analysis’’ (p= 0.03). At V4, we report statistically significant differences in meso-pic CS at 20.7 cpd, mesopic CS at 1.5 cpd under high glare conditions, and light/dark adaptation compar-ative analysis between the lower and the upper MP tertile groups (p< 0.05) Further study into therelationship between MP and VP is warranted, with particular attention directed towards individualswith low MP and suboptimal VP.

Date:

13/01/2011

Rights: © Public
Suggested citation:

Nolan JM, Loughman J, Akkali MC, Stack J, Scanlon G, Davison P, Beatty S. (2011) The impact of macular pigment augmentation on visual performancein normal subjects: COMPASS [Online]. Available from: http://publichealthwell.ie/node/1264343 [Accessed: 15th September 2019].

  

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Contributor:

Nutritional Research Centre Ireland (NRCI)
 
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