menu ☰
menu ˟

Immune modulation: IL-1, master mediator or initiator of inflammation

Region:
Description:

Interleukin-1 (IL-1) lies at the center of the inflammatory response. This proinflammatory
cytokine was first pinned down for its ability to induce fever, and was
later assigned additional biological functions including neutrophil recruitment,
lymphocyte activation and induction of inflammatory mediators1. Excessive
production of IL-1β drives the recurrent episodes of fever and systemic inflammation
in certain autoinflammatory diseases, linked to mutations in genes regulating innate
immunity; such conditions include familial cold autoinflammatory syndrome (FCAS)
and Muckle-Wells syndrome (MWS)2, as well as gout, a condition where IL-1β
induced by monosodium urate crystals (MSU) causes inflammatory response in joints.

Format:

application/pdf

Related: http://dx.doi.org/10.1038/nm1209-1363
Suggested citation:

. () Immune modulation: IL-1, master mediator or initiator of inflammation [Online]. Available from: http://publichealthwell.ie/node/635996 [Accessed: 21st September 2019].

  

View your saved citations and reading lists

Contributor:


 
Click here to view all the resources gathered from this organisation's website.