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Hepatitis C virus infection epidemiology among people who inject drugs in Europe: a systematic review of data for scaling up treatment and prevention.

Creator:

Lucas Wiessing, Marica Ferri, Bart Grady, Maria Kantzanou, Ide Sperle, Katelyn J Cullen, Angelos Hatzakis, Maria Prins, Peter Vickerman, Jeffrey V Lazarus, Vivian D Hope, Catharina Matheï

Catalogue: Research and Evaluation
Report
Type: Report
Region: Republic of Ireland
Northern Ireland
Description:

Background People who inject drugs (PWID) are a key population affected by hepatitis C virus (HCV). Treatment options are improving and may enhance prevention; however access for PWID may be poor. The availability in the literature of information on seven main topic areas (incidence, chronicity, genotypes, HIV co-infection, diagnosis and treatment uptake, and burden of disease) to guide HCV treatment and prevention scale-up for PWID in the 27 countries of the European Union is systematically reviewed. Methods and findings We searched MEDLINE, EMBASE and Cochrane Library for publications between 1 January 2000 and 31 December 2012, with a search strategy of general keywords regarding viral hepatitis, substance abuse and geographic scope, as well as topic-specific keywords. Additional articles were found through structured email consultations with a large European expert network. Data availability was highly variable and important limitations existed in comparability and representativeness. Nine of 27 countries had data on HCV incidence among PWID, which was often high (2.7-66/100 person-years, median 13, Interquartile range (IQR) 8.7â?"28). Most common HCV genotypes were G1 and G3; however, G4 may be increasing, while the proportion of traditionally â?~difficult to treatâ?T genotypes (G1+G4) showed large variation (median 53, IQR 43â?"62). Twelve countries reported on HCV chronicity (median 72, IQR 64â?"81) and 22 on HIV prevalence in HCV-infected PWID (median 3.9%, IQR 0.2â?"28). Undiagnosed infection, assessed in five countries, was high (median 49%, IQR 38â?"64), while of those diagnosed, the proportion entering treatment was low (median 9.5%, IQR 3.5â?"15). Burden of disease, where assessed, was high and will rise in the next decade. Conclusion Key data on HCV epidemiology, care and disease burden among PWID in Europe are sparse but suggest many undiagnosed infections and poor treatment uptake. Stronger efforts are needed to improve data availability to guide an increase in HCV treatment among PWID.

Date:

01/07/2014

Rights: Public
Suggested citation:

Lucas Wiessing, Marica Ferri, Bart Grady, Maria Kantzanou, Ide Sperle, Katelyn J Cullen, Angelos Hatzakis, Maria Prins, Peter Vickerman, Jeffrey V Lazarus, Vivian D Hope, Catharina Matheï. (2014) Hepatitis C virus infection epidemiology among people who inject drugs in Europe: a systematic review of data for scaling up treatment and prevention. [Online]. Available from: http://publichealthwell.ie/node/796956 [Accessed: 20th October 2019].

  

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Contributor:

National Drugs Library
 
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