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Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population

Creator:

HAWI, ZIARIH; GILL, MICHAEL; MC CARRON, MARY;

Institution: Nature Publishing Group
Subject Keywords: attention deficit hyperactivity disorder (ADHD); dopamine; dopa decarboxylase; association; haplotype based haplotype relative risk (HHRR);
Region: Republic of Ireland
Description:

Dopa decarboxylase (DDC) is an enzyme which catalyses the decarboxylation of both dopa to dopamine and L-5 hydroxytryptophan to serotonin. Both catecholamines are major neurotransmitters of the mammalian nervous system. It has been suggested that genes involved in the dopaminergic system play a primary role in predisposing to attention deficit hyperactivity disorder (ADHD). In this study, the 4-bp insertion/deletion variant mapped to the first neuronally expressed exon 1 at the dopa decarboxylase gene and two microsatellite markers flanking the gene were investigated for possible association with ADHD. Using HHRR, we observed an increased transmission (though not significant) of the 4-bp insertion (allele 1) to ADHD cases (chi2 = 2.72, P = 0.1, RR = 1.25). However marginally significant excess transmission of allele 10 (213 bp) of the 3' microsatellite D7S2422 (~0.75 cM distal to dopa decarboxylase gene) was found (chi2 = 4.2, P = 0.04, RR=1.48). Interestingly, a haplotype containing both alleles is transmitted more frequently (chi2= 5, P = 0.025). Analysing data by the sex of transmitting parent showed a greater relative risk for paternal transmission of the 4-bp insertion allele and allele 10 of the D7S2422 (RR = 1.48 and 1.63 respectively). This provides preliminary evidence that this locus or a closely mapped DNA variant may be involved in the genetic susceptibility to ADHD. However, further studies are required to either confirm or refute these observations.

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Related: http://www.nature.com/mp/journal/v6/n4/full/4000903a.html
Suggested citation:

HAWI, ZIARIH; GILL, MICHAEL; MC CARRON, MARY; . () Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population [Online]. Available from: http://publichealthwell.ie/node/624223 [Accessed: 16th June 2019].

  

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