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Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98.

Creator:

Meagher, David; Morandi, Alessandro; Inouye, Sharon K; Ely, Wes; Adamis, Dimitrios; MacLullich, Alasdair J; Rudolph, James L; Neufeld, Karin; Leonard, Maeve; Bellelli, Giuseppe; Davis, Daniel; Teodorczuk, Andrew; Kreisel, Stefan; Thomas, Christine; Hasemann, Wolfgang; Timmons, Suzanne; O'Regan, Niamh; Grover, Sandeep; Jabbar, Faiza; Cullen, Walter;

Institution: BioMed Central
Subject Keywords: delirium; classification; diagnosis; cognition; neurocognitive disorders; dementia;
Region:
Description:

Background: The Diagnostic and Statistical Manual fifth edition (DSM-5) provides new criteria for delirium
diagnosis. We examined delirium diagnosis using these new criteria compared with the Diagnostic and Statistical
Manual fourth edition (DSM-IV) in a large dataset of patients assessed for delirium and related presentations.
Methods: Patient data (n = 768) from six prospectively collected cohorts, clinically assessed using DSM-IV and the
Delirium Rating Scale-Revised-98 (DRS-R98), were pooled. Post hoc application of DRS-R98 item scores were used to
rate DSM-5 criteria. ‘Strict’ and ‘relaxed’ DSM-5 criteria to ascertain delirium were compared to rates determined by
DSM-IV.
Results: Using DSM-IV by clinical assessment, delirium was found in 510/768 patients (66%). Strict DSM-5 criteria
categorized 158 as delirious including 155 (30%) with DSM-IV delirium, whereas relaxed DSM-5 criteria identified
466 as delirious, including 455 (89%) diagnosed by DSM-IV (P <0.001). The concordance between the different
diagnostic methods was: 53% (ĸ = 0.22) between DSM-IV and the strict DSM-5, 91% (ĸ = 0.82) between the DSM-IV
and relaxed DSM-5 criteria and 60% (ĸ = 0.29) between the strict versus relaxed DSM-5 criteria. Only 155 cases were
identified as delirium by all three approaches. The 55 (11%) patients with DSM-IV delirium who were not rated as
delirious by relaxed criteria had lower mean DRS-R98 total scores than those rated as delirious (13.7 ± 3.9 versus
23.7 ± 6.0; P <0.001). Conversely, mean DRS-R98 score (21.1 ± 6.4) for the 70% not rated as delirious by strict DSM-5
criteria was consistent with suggested cutoff scores for full syndromal delirium. Only 11 cases met DSM-5 criteria
that were not deemed to have DSM-IV delirium.
Conclusions: The concordance between DSM-IV and the new DSM-5 delirium criteria varies considerably
depending on the interpretation of criteria. Overly-strict adherence for some new text details in DSM-5 criteria
would reduce the number of delirium cases diagnosed; however, a more ‘relaxed’ approach renders DSM-5 criteria
comparable to DSM-IV with minimal impact on their actual application and is thus recommended

Suggested citation:

Meagher, David; Morandi, Alessandro; Inouye, Sharon K; Ely, Wes; Adamis, Dimitrios; MacLullich, Alasdair J; Rudolph, James L; Neufeld, Karin; Leonard, Maeve; Bellelli, Giuseppe; Davis, Daniel; Teodorczuk, Andrew; Kreisel, Stefan; Thomas, Christine; Hasemann, Wolfgang; Timmons, Suzanne; O&#039;Regan, Niamh; Grover, Sandeep; Jabbar, Faiza; Cullen, Walter; . () Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98. [Online]. Available from: http://publichealthwell.ie/node/856669 [Accessed: 21st September 2019].

  

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