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A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Creator:

Frayling, T. M. et al

Subject Keywords: Study of genetic factors linked to the predisposition of obesity
Topic: Obesity
Cardiovascular Health (Draft)
Type: Report
Region: United Kingdom
Description:

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes susceptibility genes identified a common variant in the FTO gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had a 1.67-fold increased risk of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.

Date:

06/04/2007

Rights: © Authors
Suggested citation:

Frayling, T. M. et al. (2007) A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity [Online]. Available from: http://publichealthwell.ie/node/3958 [Accessed: 27th June 2019].

  

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