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Macular Carotenoids and Age-related Maculopathy


O'Connell E, Neelam K, Nolan JM, Au Eong KG, Beatty S

Subject Keywords: Nutrition, Ageing, Older People, Mental Health, Alzheimer's Disease
Catalogue: Systematic Reviews
Type: Report
Region: Republic of Ireland

AbstractLutein (L) and zeaxanthin (Z) are concentrated at the macula, where they are collectivelyknown as macular pigment (MP), and where they are believed to play a major role in protectingretinal tissues against oxidative stress. Whilst the exact pathogenesis of age-related maculopathy(ARM) remains unknown, the disruption of cellular processes by oxidative stress may play animportant role. Manipulation of dietary intake of L and Z has been shown to augment MP,thereby raising hopes that dietary supplementation with these carotenoids might prevent, delay,or modify the course of ARM. This article discusses the scientific rationale supporting thehypothesis that L and Z are protective against ARM, and presents the recent evidence germaneto this theor.



Rights: © Public
Suggested citation:

O'Connell E, Neelam K, Nolan JM, Au Eong KG, Beatty S. (2006) Macular Carotenoids and Age-related Maculopathy [Online]. Available from: [Accessed: 16th September 2019].


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