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Antioxidants for chronic kidney disease


Jun, M., et al

Subject Keywords: Antioxidant therapy, Mortality, Cardiovascular event, CKD stages 3 to 5, Dialysis, Kidney transplantation, Patient
Topic: Chronic Conditions
Chronic Conditions
Type: Article
Region: International (other)

People with chronic kidney disease (CKD) have high risk of developing heart disease and dying prematurely. Although heart disease has many causes, damage caused by poor oxygen exchange in the body's cells (oxidative stress) is thought to be a major problem. People with CKD often have evidence of oxidative stress and this is positively associated with the rate of kidney disease progression. We assessed current evidence to evaluate how antioxidant therapy influenced outcomes for patients with CKD. Overall, we found that antioxidant therapy did not reduce the risk of heart disease or death in people with CKD, but that this could vary depending on CKD stage. There was some evidence to suggest that people on dialysis may benefit from antioxidant treatment, and that these therapies could reduce the risk of kidney disease becoming worse. However, these results are based on very limited evidence and further studies are needed to confirm if antioxidant therapy could be of benefit for people with CKD.



Rights: © The Cochrane Collaboration
Suggested citation:

Jun, M., et al. (2012) Antioxidants for chronic kidney disease [Online]. Available from: [Accessed: 19th August 2019].


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