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Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

Creator:

Alzheimer's & Dementia The Journal of the Alzheimer's Association

Type: Report
Region: Republic of Ireland
Northern Ireland
Description:

Abstract  Blood proteins and their complexes have become the focus of a great deal of interest in the context of their potential as biomarkers of Alzheimer's disease (AD).  We used a SOMAscan assay for quantifying 1001 proteins in blood samples from 331 AD, 211 controls, and 149 mild cognitive impaired (MCI) subjects.  The strongest associations of protein levels with AD outcomes were prostate-specific antigen complexed to ?1-antichymotrypsin (AD diagnosis), pancreatic prohormone (AD diagnosis, left entorhinal cortex atrophy, and left hippocampus atrophy), clusterin (rate of cognitive decline), and fetuin B (left entorhinal atrophy).  Multivariate analysis found that a subset of 13 proteins predicted AD with an accuracy of area under the curve of 0.70. Our replication of previous findings provides further evidence that levels of these proteins in plasma are truly associated with AD.  The newly identified proteins could be potential biomarkers and are worthy of further investigation.

Date:

08/07/2014

Rights: Public
Suggested citation:

Alzheimer's & Dementia The Journal of the Alzheimer's Association. (2014) Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology [Online]. Available from: http://publichealthwell.ie/node/788557 [Accessed: 17th November 2019].

  

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Contributor:

CARDI
 
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