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A seminar on alcohol and pregnancy.

. Western Region Drug and Alcohol Task Force Alcohol consumption, Pregnancy Western Region Drug and Alcohol Task Force. (2017) A seminar on alcohol and pregnancy. In: Alcohol and pregnancy, 26 September, Connaght Hotel, Galway. The aim of this seminar was ...

TIG- Notes and Action Points- 11 January 2017

TIG- Notes and Action Points- 11 January 2017 Department of Health (Northern Ireland) Agendas and minutes, Health policy, Transformation Programme Transformation Implementation Group (TIG)- Notes and Action Points- 11 January 2017 Research and Evaluation ...

Letters and advice on the regulation of medicines 2017

Letters and advice on the regulation of medicines issued 2016 Department of Health (Northern Ireland) Guidance literature, Pharmacy, Regulation of medicines Letters and advice on the regulation of medicines issued 2016 Research and Evaluation Other Output ...

Appointments to the Safeguarding Board for NI (SBNI) February 2017

The Department of Health is seeking to appoint one (1) Non-Executive Chair and two (2) Non-Executive members to the Safeguarding Board for NI (SBNI). Department of Health (Northern Ireland) Forms, Governance in health and social care The Department of Hea ...

Physical activity for pregnant women infographic

Physical activity for pregnant women infographic Department of Health (Northern Ireland) Guidance literature, Nursing and allied health professionals, Professional medical and environmental health advice, Public health policy and advice Physical activity ...

Measles: Don't let your child catch it (poster)

This poster encourages protection against measles infection by getting the measles/mumps/rubella vaccine. Public Health Agency Vaccination, Measles This poster encourages protection against measles infection by getting the measles/mumps/rubella vaccine. R ...

Speech by Catherine Byrne. Minister of State for Health Promotion and the National Drugs Strategy.

. Catherine Byrne Drugs Misuse Speech by Catherine Byrne. Minister of State for Health Promotion and the National Drugs Strategy. In: Launch of Reducing harm, supporting recovery – A health led response to drug and alcohol use in Ireland 2017-2025., 17 Jul ...

Speech by An Taoiseach Mr Leo Varadkar TD.

. Leo Varadkar Substance Misuse, Drug Problems In 2014- the most recent year that we have figures for- there were 697 drug-related deaths in this country. Three-quarters were male and half were under the age of 40. That’s more than three times the number o ...

Speech by Simon Harris TD, Minister for Health.

. Simon Harris Drug Misuse, Alcohol Consumption Harris, Simon (2017) Speech by Simon Harris TD, Minister for Health. In: Launch of Reducing harm, supporting recovery – A health led response to drug and alcohol use in Ireland 2017-2025., 17 July 2017, Dubli ...

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis

During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to in ...

First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer

Nivolumab has been associated with longer overall survival than docetaxel among patients with previously treated nonâ?"small-cell lung cancer (NSCLC). In an open-label phase 3 trial, we compared first-line nivolumab with chemotherapy in patients with ...

Navigating the challenges of digital health innovation: considerations and solutions in developing online and smartphone-application-based interventions for mental health disorders

This article presents an analysis of challenges and considerations when developing digital mental health innovations. Recommendations include collaborative working between clinicians, researchers, industry and service users in order to successfully naviga ...

Shifting the optimal stiffness for cell migration

Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell m ...

The relationship between statins and breast cancer prognosis varies by statin type and exposure time: A meta-analysis

Background:Breast cancer is the most common cancer in females. The effects of statins on breast cancer prognosis have long been controversial, so it is important to investigate the relationship between statin type, exposure time, and breast cancer prognos ...

Tracking the Evolution of Non-Small-Cell Lung Cancer

Among patients with nonâ?"small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to cl ...

Design and preliminary analysis of a vaginal inserter for speculum-free cervical cancer screening

Objective Cervical cancer screening usually requires use of a speculum to provide a clear view of the cervix. The speculum is one potential barrier to screening due to fear of pain, discomfort and embarrassment. The aim of this paper is to present and dem ...

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility. In cells bearing such heterozygous mutations, we find that a cellular metabolite and ubiquitous environmental toxin, formaldehyde, stalls and destabilizes DNA ...

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

Although targeted therapies are often effective systemically, they fail to adequately control brain metastases. In preclinical models of breast cancer that faithfully recapitulate the disparate clinical responses in these microenvironments, we observed th ...

Dietary sugar intake increases liver tumor incidence in female mice

Overnutrition can promote liver cancer in mice and humans that have liver damage caused by alcohol, viruses, or carcinogens. However, the mechanism linking diet to increased liver tumorigenesis remains unclear in the context of whether tumorigenesis is se ...

Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data

Background Thrombocytosis (raised platelet count) is an emerging risk marker of cancer, but the association has not been fully explored in a primary care context. Aim To examine the incidence of cancer in a cohort of patients with thrombocytosis, to deter ...