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Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation

Creator:

Age and Ageing

Type: Report
Region: Republic of Ireland
Northern Ireland
Description:

1 Centro per la Salute dell'Anziano - Area di Geriatria, Università Campus Bio-Medico, Rome, Italy2 Department of Aging and Geriatric Research, University of Florida - Institute on Aging, Gainesville, FL, USA3 Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Università Cattolica del Sacro Cuore, Rome, Italy Address correspondence to: M. Cesari, Centro per la Salute dell'Anziano - Area di Geriatria, Università Campus Bio-Medico, Via Alvaro del Portillo 5, 00128 Rome, Italy. Tel: +39 (06) 2254-1654; Fax: +39 (06) 2254-1602. E-mail: macesari@gmail.com Background: the existence of a relationship among inflammation, high-density lipoprotein cholesterol (HDL-C) and physical function has been suggested. Objective: the aim of the study is to investigate the possible interaction of HDL-C on inflammation and physical function. Design: cross-sectional study. Setting: town of Tuscania (Italy). Subjects: all the 329 community-dwelling older persons aged 75 years (mean age 79.8 ± 5.2 years, women 56.2%). Methods: HDL-C, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Activities of daily living (ADL), instrumental ADL (IADL) and 4-m walking speed were assessed. Linear regression models were performed. Results: given the multiple significant interactions, models were stratified according to HDL-C concentrations. In participants with normal HDL-C concentrations, only IL-6 showed a significant association with IADL (β = –0.439, SE = 0.176, P = 0.01). In participants with low HDL-C concentrations, all three inflammatory biomarkers were significantly associated with 4-m walking speed and IADL. IL-6 was also significantly associated with ADL (β = –0.755, SE = 0.259, P = 0.006), whereas borderline significances were reported for CRP and ESR. Conclusions: the association between inflammation and physical function is particularly enhanced in elders with low HDL-C concentrations. Though HDL-C may merely act as a wellbeing index, HDL-C concentrations should be considered in studies evaluating inflammation and physical function.  Keywords: HDL cholesterol, physical function, inflammation, older persons, elderly

Date:

09/11/2009

Rights: Public
Suggested citation:

Age and Ageing. (2009) Interaction of HDL cholesterol concentrations on the relationship between physical function and inflammation [Online]. Available from: http://publichealthwell.ie/node/9645 [Accessed: 14th November 2019].

  

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