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Arthritis Research & Therapy

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Low-field magnetic resonance imaging study on carpal arthritis in systemic sclerosis- low grade erosive arthritis of carpal bones is an unexpected and frequent disease manifestation

IntroductionTo assess the prevalence and characteristics of subclinical arthritis of carpal and metacarpophalangeal joints in patients with systemic sclerosis (SSc). Methods: Low-field (0.2 T) magnetic resonance imaging (MRI) was performed in consecutive p ...

OPN gene polymorphism influence the risk of knee OA and OPN levels in synovial fluid in a Chinese population

IntroductionA body of studies suggests the role of Osteopontin (OPN) in onset and development of Osteoarthritis (OA), however, the association between OPN polymorphisms and OA susceptibility as well as its clinical features has not been reported. Methods: ...

Persistence of antibody response 1.5 years after vaccination using 7-valent pneumococcal conjugate vaccine in patients with arthritis treated with different anti-rheumatic drugs

IntroductionThe aim of this study is to explore the persistence of antibody response 1.5 years after vaccination using 7-valent pneumococcal conjugate vaccine in patients with rheumatoid arthritis (RA) or spondylarthropathy (SpA) treated with different ant ...

Atherosclerotic cardiovascular disease and dermatomyositis: an analysis of the Nationwide Inpatient Sample survey

IntroductionIncreased rates of cardiovascular disease are implicated in several rheumatologic diseases. Our aim was to characterize dermatomyositis hospitalizations and evaluate cardiovascular-associated mortality in this patient population. Methods: We ex ...

Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials

IntroductionWhile the safety of celecoxib has been investigated, there are limited data available on complications affecting the entire (upper and lower) gastrointestinal (GI) tract, with no patient-level pooled analyses of upper and lower GI outcomes avai ...

MMP13 is a critical target gene during the progression of osteoarthritis

IntroductionOsteoarthritis (OA) is a degenerative joint disease affecting a large population of people. The mechanism of this highly-prevalent disease is not fully understood. Currently there is no effective disease-modifying treatment for OA. ...

Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis- a systematic review of the literature

IntroductionUltrasonography (US) might have an added value to clinical examination in diagnosing early rheumatoid arthritis (RA) and assessing remission of RA. We aimed to clarify the added value of US in RA in these situations performing a systematic revi ...

Predictors of Chikungunya rheumatism: a prognostic survey ancillary to the TELECHIK cohort study

IntroductionLong-lasting relapsing or lingering rheumatic musculoskeletal pain (RMSP) is the hallmark of Chikungunya virus (CHIKV) rheumatism (CHIK-R). Little is known on their prognostic factors. The aim of this prognostic study was to search the determin ...

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests

IntroductionMicrocirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patie ...

Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis

IntroductionSystemic sclerosis (SSc) is more prevalent in women. Our goal is to determine the effects of estradiol (E2) on the development of fibrosis and compare circulating levels of estrogens in SSc patients and healthy controls. Methods: Using primary ...

The spectrum of renal thrombotic microangiopathy in lupus nephritis

IntroductionAmong various lupus renal vascular changes, thrombotic microangiopathy (TMA) presented with most severe clinical manifestations and high mortality. The pathogenesis of TMA in systemic lupus erythematosus (SLE) was complicated. ...

Association of the AIRE gene with susceptibility to rheumatoid arthritis in an European population: a case control study

IntroductionAIRE is a transcriptional regulator playing a functional role in thymocyte education and negative selection by controlling the expression of peripheral antigens in the thymus. Recently, the AIRE gene was identified as a genetic risk factor for ...

Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency

IntroductionInterleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work suggested implication of the IL-33/ST2 axis in the pathogenesis of human and mouse arthritis. Here, we directly investigated the role of ...

Scoring radiographic progression in ankylosing spondylitis: Should we use the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) or the Radiographic Ankylosing Spondylitis Spinal Score (RASSS)?

IntroductionRadiographic damage is one of the core outcomes in axial SpA and is usually assessed with the modified Stoke Ankylosing Spondylitis (AS) Spine Score (mSASSS). Alternatively, the Radiographic AS Spinal Score (RASSS) is proposed, which includes t ...

(Auto)immunity to cartilage matrix proteins: a time bomb?

Geng and colleagues consolidate and detail the role of cartilage oligomeric matrix protein (COMP) as a (potential) autoantigen in experimental and human arthritis, a finding also supported by the detection of COMP fragments and anti-COMP antibodies in rheu ...

Expression of regulatory receptors on gamma delta T Cells and their cytokine production in Behcet's disease

IntroductionBehcet's disease (BD) is a multisystemic disorder with muco-cutaneous, ocular, arthritic, vascular or central nervous system involvement. The role of gamma delta T cells is implicated in BD. The activation status of gamma delta T cells and ...

Impaired beta cell function is present in non-diabetic rheumatoid arthritis patients

IntroductionTo investigate how markers of beta cell secretion (proinsulin processing metabolites) are expressed in rheumatoid arthritis (RA) patients and their potential relationship with the insulin resistance (IR) observed in these patients. Methods: 101 ...

Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study

IntroductionThe diagnostic, predictive and prognostic role of anti-cyclic citrullinated peptide (CCP) antibodies in rheumatoid arthritis (RA) patients is widely accepted. Moreover, detection of these antibodies in subjects presenting with undifferentiated ...

CCN4 induces IL-6 production through avb5 receptor, PI3K, Akt, and NF-kB singling pathway in human synovial fibroblasts

IntroductionOsteoarthritis (OA) is the most common degenerative joint disease that involving in degradation of articular cartilage. The exact etiology of OA is not completely understood. CCN4 is related to up-regulation in the cartilage of patient with ost ...

Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus

IntroductionOsteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. ...

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Peer-reviewed research articles are not included in the Health Well's catalogues which principally focus on "grey literature". 

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