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Variations in sex steroid priming for growth hormone stimulation testing in UK

27 Oct 2016

Identifying growth hormone deficiency (GHD) can be a diagnostic challenge. In clinical practice, it can be difficult to differentiate among GHD, idiopathic short stature or constitutional delay of growth and puberty. A combination of auxological data, insulin-like growth factor 1 activity, neuroimaging and detailed clinical history is used alongside growth hormone stimulation tests (GHSTs).

There is variation in UK practice on how children are tested for GHD.1 GH treatment is expensive as well as burdensome to the patient.

It is well known that sex steroids augment the GH response to stimulation. Administration of sex steroids prior to GHST is thought to improve the accuracy of diagnosis with several studies demonstrating enhanced diagnostic efficiency with priming.2 Despite a National Institute for Health and Care Excellence (NICE) guidance on the use of growth hormone,3 there are no guidelines on age, preparation, route of administration or dosage for appropriate...

Click here to view the full article which appeared in Archives of Disease in Childhood