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Letter to the editor re: “Women with double primary cancers of the colorectum and endometrium: do they have Lynch syndrome?” from T. Song and colleagues

29 Nov 2015

We read with interest the report from Song et al. [1] who evaluated 15 women identified at a single institute with double primary cancers of the colorectum and endometrium. They report that 66% of the women in this cohort met the criteria for suspected Lynch Syndrome (LS, based on tumour molecular features of mismatch repair (MMR) deficiency) and/or clinically-defined LS (based on family history). Clinically-defined LS was described as “revised Amsterdam criteria”, but also as “family history of at least one first-degree relative with a Lynch syndrome-related cancer” [1] – which does not capture all features of the Amsterdam II criteria [2].

Click here to view the full article which appeared in European Journal of Obstetrics & Gynecology and Reproductive Biology