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[Correspondence] Stem cells in age-related macular degeneration and Stargardt's macular dystrophy – Authors' reply

04 Jul 2015

We thank Janet Sunness and Guo-You Zhang and colleagues for their comments on our Article.1 Sunness asserts that transplantation of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) into patients with advanced dry age-related macular degeneration and Stargardt's disease needs to be tested. We report only visual improvements as noted during the course of a phase 1 safety trial. As mentioned in our Article,1 many potential explanations are available for these observations other than an actual functional improvement, including those suggested by Sunness.

Click here to view the full article which appeared in The Lancet