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[Comment] Augmentation treatment for α1 antitrypsin deficiency

27 May 2015

α1 antitrypsin is a serine antiprotease secreted by the liver.1,2 Its main function is inhibition of neutrophil elastase, a non-specific protease released by activated or dying neutrophils. In individuals with healthy concentrations of α1 antitrypsin, the fragile alveolar structures of the lung parenchyma are protected from this protease (figure).

Click here to view the full article which appeared in The Lancet