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Aortic Calcifications Present the Next Challenge After TAVR

17 Mar 2015

In the presence of aortic stenosis, the left ventricle (LV) faces a double challenge: a valvular load and an arterial load (1). Transcatheter aortic valve replacement (TAVR) has now become a safe and effective alternative to surgery in patients with a contraindication or at high risk (2). Because patients considered for TAVR are elderly, implying that they often have a markedly remodeled aorta, the arterial component of the LV load is likely to be sizable; yet, the precise impact of aortic remodeling on cardiac outcomes after TAVR has never been tackled. We examined the effect of ascending aortic calcifications (AAC) measured by computed tomography (CT) on a composite endpoint encompassing cardiac mortality (from heart failure [HF], myocardial infarction [MI], or sudden death) and hospitalization for HF following TAVR with Edwards Sapien devices (Edwards Lifesciences, Irvine, California) in 127 consecutive patients. Patients provided written informed consent and the study received ethical committee approval.

Click here to view the full article which appeared in Journal of the American College of Cardiology Current Issue